WebOct 1, 2003 · Tendamistat is a strong inhibitory protein of porcine pancreatic alpha-amylase (PPA) with a K(i) value of 0.2 nM. To develop potent alpha-amylase inhibitors, we synthesized six odd-length cyclic ... WebTendinitis is an inflammation of tendons. Tendons join muscles to bones. Tendinitis can occur in the fingers, thumbs, wrists, elbows, knees, and thighs. The most likely cause is …

PubMed

WebInhibition of the enzyme's activity would reduce glucose absorption by the small intestine. Our objective was to develop small peptides based on essential binding elements of the natural protein inhibitor, Tendamistat. These smaller analogs may be better studied structurally and conformationally to help us understand molecular-level interactions. WebJul 16, 2003 · The crystal structure of the proteinaceous alpha-amylase inhibitor tendamistat has been determined at 100 K to a resolution of 0.93 A. The final R factor … strathroy beer store bottle return

Design, Synthesis, and Evaluation of a Depsipeptide Mimic of Tendamistat

WebBiological and Structural Properties of Cyclic Peptides Derived from the α-Amylase Inhibitor Tendamistat. Bioscience, Biotechnology, and Biochemistry 1998, 62 (8) , 1621-1623. WebJul 22, 1997 · The role of preformed correct side chain interactions, such as disulfide bonds, on protein folding kinetics is still not well understood. We investigated the effect of disulfide bond replacements on folding and stability of the small β-sheet protein tendamistat. Tendamistat folds very fast (τ = 10 ms at pH 7 in water) and without detectable … WebTendamistat is a strong inhibitory protein of porcine pancreatic alpha-amylase (PPA) with a K(i) value of 0.2 nM. To develop potent alpha-amylase inhibitors, we synthesized six odd-length cyclic peptides (5-15 residues) and four even-length cyclic peptides (10 and 12 residues) having the inhibitory sequence of tendamistat. round glasses tinted black