Sunitinib solubility dcm
WebMelting point: –97.1 °C Density: d 4 201.327 g/mL Solubility: Slightly soluble (1.38 g/100 mL) in water at 20 °C; soluble in carbon tetrachlo- ride; miscible in ethanol, diethyl ether, and dimethylformamide Volatility: Vapour pressure, 58.2 kPa at 25 °C; relative vapour density (air = 1), 2.93 (Verschueren, 1996) WebSunitinib (malate) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, sunitinib (malate) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Sunitinib (malate) has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2) using this method.
Sunitinib solubility dcm
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WebNov 11, 2024 · Sunb-malate has limited solubility in DCM, but can be dissolved in DMSO up to 100 mg/mL. The Sunb-malate DMSO solution and PLGA DCM solution were mixed at … WebApr 6, 2024 · Moreover, due to its poor water solubility, protein binding, and accumulation in liver tissue, it is difficult to compare sunitinib malate—the commercial formulation—with the hydrochloride salt used in DEB . Nevertheless, Fuchs et al. demonstrated that sunitinib (2 mg/kg) tumor delivery via DEB increased the intratumoral concentration up to ...
WebSunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib … WebAug 7, 2024 · In mRCC patients who received sunitinib 50 mg/day according to the 4/2 schedule, four soluble biomarkers of sunitinib activity were investigated on days 1 and 28 of each cycle (Deprimo et al., 2007). At the end of the first cycle, plasma concentrations of VEGF and placental growth factor (PlGF) were increased, whereas those of soluble …
WebNov 11, 2024 · Sunb-malate has limited solubility in DCM, but can be dissolved in DMSO up to 100 mg/mL. The Sunb-malate DMSO solution and PLGA DCM solution were mixed at 1:4 ratio to form a homogeneous organic phase, which was used to prepare Sunb-malate MS using the emulsion solvent evaporation method. WebAs the trifluoroacetate salt increased the solubility of 16 in DCM, ... Compd. 54 is more potent than sunitinib not only against FLT3-WT AML cells but also active against sunitinib-resistant FLT3-ITD AML cells. This study demonstrates the significance of dual Aurora B/FLT3 inhibitors for the development of potential agents to treat AML.
WebSolubility: Soluble in DMSO at 40 mg/mL; soluble in ethanol at 1.4 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 …
WebMar 1, 2024 · Recently, it has also been studied as a potential solubilizer in the solubility enhancement of various poorly soluble drugs, including sunitinib malate, flufenamic acid, sinapic acid, apremilast ... restaurants with free delivery todayWebSunitinib malate has been used: to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis; as a reference molecule to compare its docking energies … restaurants with frozen drinksWebSolubility (25°C) Chemical Information Download Sunitinib (SU11248) malate SDF In vivo Formulation Calculator (Clear solution) Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) Dosage: mg/kg Average weight of animals: g Dosing volume per animal: μL Number of animals: proximal interphalangeal creaseWebSunitinib(SU-11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFR? with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.; ... 7.85E-012 mm Hg (25 deg C, Mod-Grain method) Water Solubility Estimate from Log Kow (WSKOW v1.41): Water Solubility at 25 deg C (mg/L): 17.93 log Kow used: 2.63 (estimated) no-melting pt equation ... restaurants with fried calamari near meWebThe CHMP adopted a report on similarity of Sunitinib Accord with SomaKit, Lutathera and AYVAKYT on (Appendix 1) 10 December 2024 . 2. Scientific discussion 2.1. Introduction 2.2. Quality aspects 2.2.1. Introduction The finished product is presented as hard capsules containing 12.5, 25, 37.5 or 50 mg of sunitinib . Other ingredients are: proximal inferior wallWebIn patients who received sunitinib in Phase 3 registrational studies, pulmonary events (i.e. dyspnoea, pleural effusion, pulmonary embolism, or pulmonary oedema) were reported … proximal interactionsWebSunitinib is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 10 mg in 3.76 ml DMSO. Working concentrations and length of treatment can vary depending on … proximal interphalangeal joint arthroplasty