WebApr 7, 2024 · Ferroptosis is an iron-dependent nonapoptotic cell death driven by the accumulation of lipid reactive oxygen species (ROS). Glutathione (GSH)/glutathione peroxidase 4 (GPX4) plays a pivotal role in protecting cells from ferroptosis by hydrolyzing lipid hydroperoxides. Mounting evidence supports the crucial role of ferroptosis in tumor … WebFerroptosis can be activated by treatment with erastin or high extracellular glutamate to lead to depletion of cysteine, inhibition of glutathione (GSH) synthesis, and inactivation of the phospholipid peroxidase glutathione peroxidase 4 (GPX4), an enzyme crucial in converting toxic lipid hydroperoxides to nontoxic lipid alcohols ( 20 ).
Frontiers Post-Translational Modification of GPX4 is a Promising ...
WebGPX4 activity can be upregulated by supplementing intracellular selenium or glutathione, and also be inhibited by ferroptosis inducers such as ML162 and RSL3. These … WebApr 14, 2024 · Oppositely, Glutathione Peroxidase 4 (GPX4), a key regulator of ferroptosis , is responsible for diminishing phospholipid hydroperoxide by oxidising glutathione (GSH), which is biosynthesised by the Cystine/Glutamate Antiporter (xCT, encoded by the SLC7A11 gene) using imported cystine . Nevertheless, it remains unknown whether ferroptosis is ... grandmother message
Role of ferroptosis in lung diseases JIR
WebApr 7, 2024 · However, it is reported that ACSL4-independent ferroptosis and GPX4-independent ferroptosis could still occur. 18,20 Of special interest, ferroptosis has … WebApr 21, 2024 · GPX4 resists iron and oxygen-dependent lipid peroxidation by converting lipid peroxides (L-OOH) to non-toxic lipids and acts as the key enzyme in ferroptosis regulation. GSH is a cofactor and a synthetic … WebApr 11, 2024 · Perillaldehyde, the main component of Ammodaucus leucotrichus, downregulates GSH and GPX4 to induce ferroptosis in HL-60 cells and primary AML cells . Glycyrrhetinic acid is a bioactive compound of licorice, and its nanoparticles have been demonstrated to induce ferroptosis in AML cells through GPX4 downregulation . These … grandmother message to grandchildren